• Skip to main content
  • Skip to secondary menu
  • Skip to primary sidebar
  • Skip to secondary sidebar
  • Skip to footer

Technologies.org

Technology Trends: Follow the Money

  • Technology Events 2023-2024
  • Sponsored Post
    • Make a Contribution
  • Technology Jobs
  • Technology Markets
    • Venture Capital
  • About
  • Contact

Clover Initiates Development of Recombinant Subunit-Trimer Vaccine for Wuhan Coronavirus (2019-nCoV)

January 28, 2020 By admin Leave a Comment

Clover Biopharmaceuticals, a global clinical-stage biotechnology company focused on developing novel and transformative biologic therapies, today announced that it has initiated development of a recombinant subunit vaccine for 2019-nCoV, the newly identified coronavirus that is believed to have originated from Wuhan, China.

Since this outbreak was first reported in late-2019, the 2019-nCov virus has so far infected thousands of people and has caused over one hundred reported deaths (as of January 28, 2020). The epidemic currently appears to be in an exponential phase.

Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, 2019-nCoV is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. The trimeric S protein of 2019-nCoV is responsible for binding to host cell surface receptor ACE2 and subsequent viral entry. Symptoms in infected patients include fever, coughing and breathing difficulties, and it can be fatal.

Clover is using its patented Trimer-Tag© technology to construct a recombinant 2019-nCoV S protein subunit-trimer vaccine (S-Trimer) and will produce it via a rapid mammalian cell-culture based expression system. Clover expects to obtain highly purified S-Trimer vaccine for further preclinical safety and analysis within the next 6-8 weeks. Having its own in-house cGMP biomanufacturing capabilities, Clover would potentially be able to rapidly scale-up and produce large-quantities of a coronavirus vaccine, if a successful vaccine candidate is able to be identified.

Clover has previously developed recombinant subunit-trimer vaccines for HIV, RSV and Influenza viruses utilizing its Trimer-Tag© technology and has demonstrated that they are able to evoke protective neutralizing antibody responses in multiple animal models.

“Upon knowing the genomic DNA sequence of this newly identified 2019-nCoV last week, we immediately started designing the vaccine construct and initiated its gene synthesis. Using our proprietary Trimer-Tag© protein trimerization technology, we plan to complete constructing the expression vector for S-Trimer vaccine and produce it for further evaluation within weeks,” said Dr. Peng Liang, co-founder, Chairman and President of Clover. “We believe that S-Trimer utilizing Trimer-Tag© technology will be faster to produce and potentially safer and more effective than vaccines produced via traditional approaches that involve lengthy live viral propagation, amplification, purification and heat/chemical attenuation or inactivation processes.”

“We are excited to initiate development of the S-Trimer vaccine candidate for 2019-nCoV and hope that by leveraging our proprietary Trimer-Tag© technology and cGMP biomanufacturing capabilities, we can help support global efforts to fight the growing 2019-nCoV epidemic,” said Joshua Liang, Chief Strategy Officer and Board Director at Clover. “To this end, we recognize that collaboration will be critical to accelerating the development of a successful vaccine, and we invite any interested regulatory, academic or industry parties to contact and collaborate with us.”

Source: Clover Biopharmaceuticals
Clover Biopharmaceuticals is a global, clinical-stage, research-based biotechnology company focused on discovering, developing and commercializing transformative biologic therapies, with a focus on oncology and autoimmune diseases, as well as viral vaccines. Having raised more than US$ 100 million in total capital since 2016, Clover is utilizing its proprietary Trimer-Tag© technology platform to develop novel biologics targeting trimerization-dependent pathways. Additionally, Clover is leveraging its in-house cGMP biomanufacturing capabilities to develop select biosimilars. For more information, please visit our website: www.cloverbiopharma.com

Filed Under: Tech Tagged With: Coronavirus

Reader Interactions

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Primary Sidebar

Market Analysis

AI reality vs. myth: predictions for 2024
Cloudflare is introducing the concept of the “connectivity cloud”
Robotic Revolution: Japan’s Surging Industrial Robot Market and China’s Dominance
China’s Poaching of Water Technologies from the West: A Serious Concern
Market Scenario of China Banning Exports of Rare Earth Materials and Electric Batteries
Navigating Markets through a 4-Dimensional Research Data Model
A Markov Chain-Based Approach for Forecasting Emerging Technologies: An Extended Analysis

Market Research Media

The Evolution of RSS Feeds: A Media Analyst’s Perspective
AI-Enhanced 4-Dimensional Market Dynamics Analysis: Unveiling Trends, Segmentation, Behavior, and Evolution through Markov Chain Modeling
Autotutoring Market: Personalized Learning and Technological Innovation at the Forefront
Integration of Generative AI and Large Language Models for Enterprises
The Decline of Chinese Media Under Authoritarian Rule: Economic Implications
Algorithmic Bias in Media Recommendation Systems: Unveiling Challenges and Pursuing Fairness
U.S. Federal IT Market Forecast

Secondary Sidebar

Tech Events

Smart City Expo 2023 Reshapes Urban Futures with Unprecedented Participation and Innovation Showcase
SAP SBN User Conference is taking place on October 17-18, 2023 in Oslo, Norway
2023 European Conference on Optical Communication (ECOC) in Glasgow, Scotland, October 2-4, 2023
Bloomberg Technology Summit, October 24t, 2023, London
Imagine 2023, Edge AI Conference, September 27, 2023, Computer History Museum, Mountain View, California

Venture Capital

Silverflow Secures €15 Million Investment to Revolutionize Global Payment Processing
Myrror Security, an Israeli company specializing in application security for organizations using open-source packages, has officially launched with $6 million in seed funding
Iron Nation Launches Volunteer Emergency Impact Fund to Support Israeli Start-ups Affected by Recent Conflict
UnitX, a robotics company specializing in AI vision systems, secures $5 Million
UserEvidence, a customer voice platform, secured $9 million in Series A funding

Footer

Recent Posts

  • IBM Quantum Summit Unveils Breakthroughs: IBM Quantum Heron and System Two
  • Apple has announced the winners of the 2023 App Store® Awards
  • Aalyria and Airbus Collaborate on High-Speed Aerial and Spaceborne Networks
  • Entrepreneurship Program at Argonne National Laboratory Opens Applications for Startups
  • Toyota is nearing mass production of solid-state batteries
  • Cloudflare and Meta Partner to Democratize Access to Llama 2 Open Source Large Language Model (LLM)
  • Bridging the Semiconductor Workforce Gap: Intel’s Innovative Educational Initiatives
  • German Government and Bavaria Invest €300M in ams OSRAM Semiconductor Tech
  • Innovative Ship Concept: Providing Zero-Carbon Nuclear Energy for Defense and Disaster Relief
  • Linux Foundation Launches OpenTofu: A New Open Source Alternative to Terraform

App Coding

Building a simple SMS (Short Message Service) application using SQLite and jQuery
How to teach yourself app coding
Cybertech 2023 in Tel Aviv: Navigating the Challenges of App Security
Exploring Two Approaches to Moonshot Software Projects: 1000 Monkeys Method vs. Planned Approach
The Importance of State Management in React Apps

API Coding

Building Powerful APIs for Gaming
Can a single XML file be an API?
Mastering API Design: Principles for Creating Effective and User-Friendly Interfaces
How to built a gaming API
Is an RSS feed an API?

Blockchaining

Building a Decentralized VPN Using Blockchain Technology
Building a Secure and Decentralized Blockchain API: A Step-by-Step Guide
Exploring the Potential of Blockchain Technology: A Comprehensive Overview
Creating a Unique and Valuable Non-Fungible Token (NFT): A Step-by-Step Guide
Brands to Shop: Empowering Shopping Club Membership through Blockchain

Calendarial

Comic Con, Taking Place at the Los Angeles Convention Center, December 1-3, 2023
Smart City Expo 2023: “The New Urban Era” in a Record-Breaking Edition, November 7-9, 2023, Barcelona
Apple: “Scary Fast” virtual event, October 30, 2023
Our hearts go out to the people of Israel
The 30th annual RegTech Convention, 21-22 November 2023

Copyright © 2022 Technologies.org

Media Partners: Market Analysis & Market Research and Exclusive Domains

We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept”, you consent to the use of ALL the cookies.
Do not sell my personal information.
Cookie SettingsAccept
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checkbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
SAVE & ACCEPT